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TRIUMPH-3: Weight management in people with cardiovascular disease Additional TRIUMPH Trials: Type 2 diabetes management Chronic low back pain Metabolic dysfunction-associated steatohepatitis (MASH, formerly NASH/NAFLD) Cardiovascular and renal outcomes The TRIUMPH program has enrolled more than 5,800 participants total, making it one of the largest Phase 3 programs for an obesity medication in history

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Human GLP-1R, human DNGs, and His 6 -tagged human G 1 and G 2 were expressed in sf 9 insect cells (Expression systems) using baculovirus and then infected with three separate baculoviruses at a ratio of 5:2:2 for GLP-1R, DNGs and G 1 2