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Assessing the efficacy of GH treatment in GHD is challenging due to the difficulty in identifying biomarkers that capture both GHD-related changes and the response to GH therapy

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Comment: Many commenters alleged that, given the complexity and scale of the required data collection and analysis, conducting the survey will impose a significant burden on hospitals and that CMS's estimate of that burden grossly underestimates the cost, time and resources that will be necessary to complete the survey

Certain heart conditions , as electrolyte shifts can affect heart rhythm

This flexibility is essential in research