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Employers are balancing coverage (many see it as a competitive benefit) with tighter utilization: mandatory prior auth, step edits requiring patients to fail cheaper modalities first, periodic re-authorization, and increasingly, coupling coverage with lifestyle management programs

Badawi GH, Kawano N, Yamauchi Y, Shimada E, Sasaki R, Kubo A, Tanaka K

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doi: 10.1038/nature25986 79 WeissJMDaviesLCKarwanMIlevaLOzakiMKChengRYet al

NADPH Oxidase Inhibition Celastrol is an electrophilic triterpenoid derived from the root of the Thunder god vine Trypterygium wilfordii, that has a dual antioxidant mechanism