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Thus, low CTLA-4 expression in cytotoxic T cells (Song et al., 2013) increases the incidence of APC antigen presentation and cytotoxic T cells activation via B7 (from APC) to CD28 cytotoxic T cell binding (Abbas et al., 2019a, see Figure 1)

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Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis