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M., 3rd, Valujskikh,A., & Fairchild, R

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A recent analysis of FDA adverse event reporting system (FAERS) data from 2004 to 2020 revealed a notable association between GLP-1 RAs and malignant pancreatic neoplasms (proportional reporting ratio [PRR], 9.86) [52]

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Of note, almost half of patients treated with GLP-1-RAs also had pre-existing migraine as comorbidity (26.7% in the UCWM group), which could predispose them to worse (rather than better) headache outcomes [31], providing additional evidence of a favorable effect of GLP-1-RAs on headache improvement