143 Abubakar PantiACeSSaiduYTunauKIkechukwu EmmanuelNJimohAet al
Free carnitine directly facilitates mitochondrial fatty acid uptake and -oxidation [31], Acylcarnitines are esters formed by conjugation of free carnitine with fatty acyl groups of varying chain length, and are categorized as short-chain ( C6, e.g., acetylcarnitine C2, propionylcarnitine C3), medium-chain (C7-C12, e.g., octanoylcarnitine C8, decanoylcarnitine C10), and long-chain ( C13, e.g., palmitoylcarnitine C16, stearoylcarnitine C18) derivatives [32,33,34]
Semaglutide (Ozempic / Wegovy) targets this pathway
In the context of POTS and neuropathic dysautonomia, where blood vessels fail to constrict properly upon standing, improving endothelial health is crucial for maintaining adequate blood pressure and cerebral perfusion
Blood Flow Restriction training BFR is one tool that illustrates this well