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Protein breakdown is the main concern As a protein drug, semaglutide can undergo physical changes over time

Ozempic Lawsuit Updates October 2023 : A study published in the Journal of the American Medical Association (JAMA) provides evidence linking the use of popular weight loss medications, including Ozempic, to an increased risk of serious gastrointestinal issues, including pancreatitis, bowel obstruction, gastroparesis, and biliary disease (which affects the gallbladder)

That risk differential increased to 14 percent a year after they stopped a GLP-1, and rose to as much as 22 percent after two years off the medication

Diabetes Care 34(Suppl 2):S279-284

Clinical pharmacology of albiglutide, a GLP-1 receptor agonist