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"Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment." New England Journal of Medicine , 2025 (ATTAIN-1 trial) Eli Lilly press release: ATTAIN-2 Phase 3 topline results

In fact, the immunomodulatory effects mentioned earlier, suppression of inflammatory cytokines and enhancement of regulatory T-cell function, could theoretically have mild protective effects on thyroid tissue, though no clinical study has confirmed this

TRIUMPH-1 enrolled approximately 2,300 patients and is expected to complete around mid-year

Clinical trials show average weight loss of approximately 13.9% at the 2.4mg weekly dose over 68 weeks

What about regulatory scrutiny