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You may need to calm the system before pushing it harder
The concern is grounded in a specific physiological reality: up to 40% of total weight lost on high-efficacy GLP-1 medications is lean body mass, not fat, according to body composition studies cited in recent Harvard Science Review analysis and a Nature Reviews Endocrinology correspondence published in 2026
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Women with type 2 diabetes who take glucagon-like peptide-1 (GLP-1) analogues do not have a higher risk of breast cancer than those who take dipeptidyl peptidase-4 (DPP-4) inhibitors, results from a cohort study suggest
However, in vagotomized animals, the effect of liraglutide on body weight has not been compromised, supporting the hypothesis that gut-to-brain communication via the vagal nerve is not the main mechanism responsible for the weight loss [89]
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