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It represents the self-evolution of highly heterogeneous tumor cells, achieved through the deep interplay of multiple mechanisms under therapeutic selective pressure [12]

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evidence is largely preclinical Potent growth-factor signalling can affect blood glucose (hypoglycaemia risk) and involves proliferative pathways that need clinical oversight Screening, suitability and any monitoring are determined by the treating physician Clinical note: This card is educational and is not medical advice, a protocol or a promise of results