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The absolute abundance of these pathways was positively correlated with the area under the IPGTT curve and insulin level ( Figure 5 )

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The ADA 2026 Standards of Care now recommend GLP-1 receptor agonists with demonstrated cardiovascular benefit for patients with type 2 diabetes and established ASCVD, multiple cardiovascular risk factors, or chronic kidney disease, and note that combination with SGLT2 inhibitors may provide additive benefit

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