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Vascular dark circles result from thin periorbital skin (thinnest on body at 0.5mm vs 2mm average facial skin) allowing visualization of underlying blood vessels and pooled deoxygenated blood appearing blue-purple through skin surface

During cellular stress, AA is released from membrane phospholipids by phospholipase A (PLA2) or phospholipase C (PLC)

The clinical criterion for approval of a PA request for a non-preferred NSAID requires that the member has experienced an unsatisfactory therapeutic response or experienced a clinically significant adverse drug reaction with at least two preferred NSAIDs

The good news is that with timely medical care, many people recover fully from an acute episode, although ongoing monitoring is important to protect long-term health

Oral LC is the most convenient method of application