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Turk et al., 2018)

This imbalance between apoptosis and regeneration of pancreatic -cells is poorly understood, but several mechanisms have been proposed as triggers for the increased loss [20]

doi: 10.3389/fimmu.2019.00277 114 ParkJ.LeeJ.YeomZ.HeoD.LimY.-H

In addition, excessive NEFAs lead to increasing lipid esterification and ceramide production, causing oxidative stress, and promoting the production of NO