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Animal models, while more physiologically complex, are expensive, ethically constrained, and often poorly predictive of human pathophysiology, contributing to translational failure ( OoC platforms provide a human-relevant alternative by enabling the assessment of drug efficacy, toxicity, and pharmacokinetics under dynamic, physiologically inspired conditions

The authors would like to note that this work reflects only one type of biomolecule and other biomolecules may not yield the same effect

Combined Protein- and Ligand-Observed NMR Workflow to Screen Fragment Cocktails against Multiple Proteins: A Case Study Using Bromodomains

This formulation combines Tesamorelin, a synthetic analog of growth hormonereleasing hormone (GHRH), and Ipamorelin, a selective growth hormone secretagogue, both of which are commonly examined in laboratory environments for their influence on endocrine signaling pathways related to growth hormone regulation

Tang et al., 2013