A 2006 Achilles-detachment study by Krivic and colleagues in the same journal applied BPC-157 intraperitoneally once daily at 10 g/kg, 10 ng/kg, or 10 pg/kg for 30 days in rats and reported that tendon-to-bone tissue, which did not heal spontaneously in saline controls, recovered with BPC-157 treatment, with directionally improved load-to-failure, stiffness, Young's modulus, and collagen organization at days 121, including in animals where healing had been impaired by 1 mg/kg 6-methylprednisolone though the abstract does not report numeric effect sizes or p-values
It is intended exclusively for in vitro testing and laboratory experiments
The risk of hitting a nerve, a major blood vessel, or causing significant muscle trauma with the needle is virtually eliminated
They advised the panel to vote no
Case Series and Pilot Studies: In recent years, a few small-scale human studies have surfaced, often by clinicians using BPC-157 in practice and then writing up their observations