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If side effects are severe or persistent, healthcare providers may recommend temporarily maintaining the current dose or, in some cases, reducing the dose before attempting further increases

TJ proteins, such as the claudin family, occludin, Zona occludens 1 (ZO-1), and tricellulin, have been identified as being related to the neuro-barrier [114]

In the UK, GLP-1 receptor agonists are licensed for type 2 diabetes and, in certain cases, weight management, with rigorous MHRA and NICE oversight ensuring their safety and efficacy

These are contraindications the evaluating clinician will ask about

DePace REFERENCE [1] Mohammad MK, Pepper DJ, Kedar A, et al