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A Y1R germline deletion results in elevated osteoblast activity and mineral apposition rate, together with increased formation of highly multinucleated osteoclasts and enhanced surface area, demonstrating a negative role of Y1R on bone mass maintenance [76]

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Despite the well-established increase in IFP within breast tumors, our understanding of how breast cancer cells respond to this physical stimulus remains elusive due to the scarcity of reliable in vitro platforms that permit adjustment of pressure independent of changes in pH or the dissolved concentration of gases

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