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Further mechanistic studies showed that NNMTi increases intracellular NAD levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies

Animal and human studies have found that they could reduce symptoms of diabetic neuropathy and may have neuroprotective effects as well

TGF-beta-1 is elevated in balding scalp tissue and contributes to follicle regression

Anyway, focus on the positives I guess