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More than 6575% of osteosarcoma cases exhibit activation of the PI3K/AKT/mTOR pathway, which contributes to the poor response of patients toward doxorubicin and cisplatin treatment

2001, 7, 14901496 Clin Cancer Res 2018, 24, 32423246 DOI: 10.1158/1078-0432.CCR-17-3179 Oncologist 2018, 23, 11031108 DOI: 10.1634/theoncologist.2017-0604 Blood 2010, 116, 26182619 DOI: 10.1182/blood-2010-08-300871 Blood 2017, 130, 23732376 DOI: 10.1182/blood-2017-09-797712 Drugs 2017, 77, 16031610 DOI: 10.1007/s40265-017-0802-5 mc-MMAF ADC (mafodotin) Clin

Sometimes that signal is not as strong in some people as others, and it may not last as long, he said