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Naunyn-Schmiedeberg's Arch Pharmacol 398 , 1098310995 (2025)

It does not act on the hypothalamic-pituitary-gonadal (HPG) axis, which regulates testosterone secretion in the body

Once bound to the AR, testosterone is irreversibly converted to dihydrotestosterone (DHT) through the enzymatic action of 5- reductase (Wilborn et al., 2010)

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The before-after images thus suggest the presence of a sexual dimorphism in shape changes with weight loss in the context of the current study experimental conditions