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Clinical research priorities include properly designed human clinical trials with adequate sample sizes, appropriate controls, and validated outcome measures

Learn more: Cell by Cell Press Cell Press #neuroscience #neurology #durgdevelopment #clinicaltrials #diseasemodifyingtherapy #Alzheimer #Alzheimersdisease #dementia #cognitivedecline #tau #tauprotein #tauopathy #pathophysiology #neurodegeneration #neurodegenerativediseases #PET #PETimaging #neuroradiology #brainimaging #biomarkers #molecularimaging #tautherapy #ASO #anstisenseoligonucelotides #amyloid #immunization #ATN #immunotherapies #drugdiscovery #precisionmedicine #outcomes #outcomeresearch #trialdesign #adaptivedesign Figure: Lessons from anti-tau immunotherapies: Optimization of tau targeting and clinical trial design

Switching from semaglutide to tirzepatide: Wait one week after last semaglutide dose Start tirzepatide at 2.5mg (standard starting dose) Don't assume you can start at higher doses because you're "used to" GLP-1s Monitor for side effects as if starting fresh Switching from tirzepatide to semaglutide: Wait one week after last tirzepatide dose Start semaglutide at 0.5mg (skip the 0.25mg if you tolerated tirzepatide) Can titrate faster than first-time users Usually done to reduce costs, not improve results Why people switch: Semaglutide Tirzepatide: Want more weight loss Tirzepatide Semaglutide: Side effects too intense or cost savings Either direction: Insurance coverage changes Combining with other peptides GLP-1s work well alone but can be strategically stacked

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Conditions such as chronic kidney disease (CKD), kidney stones, or a history of urinary tract infections (UTIs) can make the kidneys more vulnerable to infection