From a safety perspective, similar to CVOTs, a higher incidence of genital mycotic infection (GMI) noted was also observed, although reassuringly, no increase in serious volume depletion, hypotension, or hypoglycemia was observed in CREDENCE or DAPA-CKD
There is no clinical data supporting concurrent use of two incretin-based medications targeting overlapping receptor pathways
Lofts change ever-so-slightly in the 3- through 5-iron, but never by more than 1 degree
However, these therapeutic measures are associated with certain limitations
We dont measure ratios of testosterone to estradiol like we do womens progesterone to estradiol however, we know where estradiol and estrone should be as well as testosterone and if estrogens are too high or testosterone too low - then bingo- weve got a problem with fat loss