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It induces delta-wave sleep (NREM stage 3-4), the most restorative stage of sleep, by modulating circadian rhythms and the balance between inhibitory serotonin/GABA systems and activating pathways

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The primary endpoint is resolution of MASH without worsening of fibrosis

both caused downregulated hepatic stearoyl-CoA desaturase 1 gene expression

Abstract Renal involvement in systemic lupus erythematosus (SLE) represents one of the most frequent organ manifestations, often leading to end-stage kidney disease (ESKD)