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Protein replacement therapy (PRT) technology permits intracellular delivery of therapeutic proteins by facilitating penetration of almost all biological membranes, without interfering with the endogenous genetic information [48]

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The mtDNA copy number in cumulus granulosa cells (CGCs) is correlated with embryo quality and implantation in patients undergoing in vitro fertilisation (IVF) procedures, and measuring copy number in CGCs can be used to assess oocyte developmental competence [52]