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The cellular necrosis after an APAP overdose leads to release of cell contents, which includes molecules termed damage-associated molecular patterns (DAMPs) that can bind to pattern recognition receptors, e.g., toll like receptors, on macrophages and trigger formation of various cytokines and chemokines [8690]

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When taken within recommended limits, this combination is considered safe for long-term use

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By contrast, generic allogeneic cells may be used for multiple patients and centrally produced from a bank of human embryonic stem cells (hESCs) or of induced pluripotent stem cells (iPSCs)

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