melatonin and glutathione Enhances Peroxidase Activity Improves Antioxidant Defense in Cryopreserved Ovarian Transplants: A Rat Model Study Melatonin and nitric oxide modulate

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10.1371/journal.pone.0095935 PLoS One

Under the excessive accumulation of reactive oxygen species (ROS), over-oxidized PUFA-containing phospholipids (PUFA-PLs) alter the membrane structure and increase its permeability, eventually leading to plasma membrane rupture and cell damage [8]