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The HCMV specific inhibitor WAY-174865 (WAY) is marked in orange

Moreover, AMPK exhibited a comparable half-life in shCtrl and shGDH1 cells in a cycloheximide (CHX) chase assay (Extended Data Fig

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Collectively, our findings establish the 1,2-dithiolane architecture as a dual-mode molecular scaffoldthrough strategic incorporation of hydroxyl or amino moieties as cargoesthat achieves orthogonal responsiveness to distinct redox regulators (e.g., thiols vs