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The dysfunction of this pathway due to reduced expression of TFEB has been implicated in the pathogenesis of AD [216]

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Within the cytosol of cells, glutathione is kept primarily in the reduced GSH form, largely by reduction of GSSG by the enzyme glutathione reductase, at the expense of NADPH: The mechanism of this reaction is complex, as the enzyme contains a pair of cysteine residues that reversibly form a disulfide bond, plus one FAD molecule (3)

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The central role of glutathione in the pathophysiology of human disease, 2007 GSH Mitochondrial Transport glutathione and mitochondrial GSH can be transported to mitochondrial matrix by different carriers, particularly the 2-oxoglutarate carrier (OGC) and the dicarboxylate carrier (DIC), located in the mitochondrial inner membrane