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This mechanism is particularly relevant for conditions characterized by profound, unremitting fatigue

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GLP-1(936) DPP-4 GLP-1(7-36) , GLP-1(7-36) .35,256,257 GLP-1(936) GLP-1 .258 GLP-1(936)

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After a 5-hour fast, mice were given water or sitagliptin (Merck Laboratories) by oral gavage at 14 g/mouse (for intestinal-selective inhibition of DPP-4, ref