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The TRIUMPH phase 3 development program is testing the efficacy of retatrutide of retatrutide for obstructive sleep apnea, weight management, and knee osteoarthritis in obese and overweight patients
474 Moreover, these agents reduce the risks of myocardial inflammation and fibrosis and improve cardiac structure and function
The phase 2 type 2 diabetes trial reported no severe hypoglycemia and no deaths, but that does not eliminate risk in broader populations [5]
Dietary Adjustments Simple dietary changes can significantly reduce digestive side effects: Eat smaller meals: Large meals can worsen nausea and stomach discomfort Choose bland foods: Avoid spicy, fatty, or heavily seasoned foods initially Stay hydrated: Drink plenty of water, especially if you experience vomiting or diarrhea Eat slowly: Take time with meals to aid digestion Timing Considerations The timing of your injection can affect side effects
Metformin is the only oral agent that when used as a monotherapy has been reported to reduce the risk of developing macrovascular complications [77]
