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The potential causes of this heterogeneity mainly include population characteristics, drug specificity, the intensity of lifestyle intervention, and the impact of comorbidities [50]

Clinical trials show varying degrees of weight loss: semaglutide typically achieves approximately 15% weight reduction over 68 weeks, while liraglutide produces about 5-8% weight loss over 56 weeks

Wulff, A

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on the contrary, it is dispersed heterogeneously, mainly as single cells, along the epithelium of the GI tract, from the stomach to the rectum with a defined cephalocaudal, crypt-to-villus in the small intestine and crypt-to-surface distribution in the colon ( Despite representing just 1% of the adult gut epithelium, in the last decade it has become clear that the EECs constitute the largest endocrine organ in mammalia ( Collectively, the EECs are responsible for the production of more than 30 different hormones that help to orchestrate the fate of the intermediary metabolism