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For these reasons, observations of dependence and abuse of prescription d-amphetamine are rare in clinical practice, and this stimulant can even be prescribed to people with a history of drug abuse provided certain controls, such as daily pick-ups of prescriptions, are put in place (Jasinski and Krishnan, 2009b)

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Notably, the inherent stability of CM-EVs appears to surpass that of many plant-derived EVs, such as those from soybeans, which often require protective coatings to withstand enzymatic degradation 25,26

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