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Its selectivity profile is closer to that of ipamorelin than to GHRP-2/6, without marked elevation of other pituitary axes

Reduces Sudden Onset of Symptoms: When doses are increased too quickly, patients are more likely to experience sudden and severe diarrhea

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In both cases, the mechanism was suggested to involve the insulin receptor and downstream signaling pathways including protein kinase B (Akt), although how DPP-4 might influence this process was not clarified