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Amino acid substitutions : Specific amino acids within the peptide backbone are reported to have been substituted or modified to improve resistance to enzymatic degradation, including by dipeptidyl peptidase-4 (DPP-4), thereby improving metabolic stability

In clinical trials, hair loss was directly proportional to the rate and total amount of weight loss in people on the drugs

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These associations persisted after adjustment for age, sex, body mass index, glycemic control, comorbidities, and screening intensity, suggesting that the observed effect extends beyond weight loss alone