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Retatrutide is an investigational triple hormone agonist (GLP-1, GIP, glucagon) showing promising early results for obesity and type 2 diabetes, while tirzepatide is an FDA-approved dual agonist (GLP-1, GIP) available for use today

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Response time may be longer, requiring patience before dose adjustment

In clinical trials of semaglutide injection for weight management, acute pancreatitis was confirmed by adjudication in 4 semaglutide-treated patients (0.2 cases per 100 patient-years) versus 1 in placebo-treated patients (less than 0.1 cases per 100 patient-years)