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Smaller, more frequent meals maintain nutrient intake without triggering the nausea that large portions can cause at this dose

In clinical trials, semaglutide showed average weight loss of about 15% over 68 weeks

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The studies mainly report results at 24, 40, 48 and 68 weeks, although weight loss was already starting in the early weeks with some users experiencing 2-5% of weight loss in the first 4 weeks

A multicenter observational study in Japan published in the Frontiers in Clinical Diabetes and Healthcare found that individuals with type 2 diabetes taking glucagon-like peptide-1 receptor agonists (GLP-1RAs) showed reduced external eating scores after 12 months of therapy Their blood sugar levels, body weight, and body fat percentage also decreased significantly Emotional and restrained eating showed only transient changes