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New England Journal of Medicine (2025) This phase 3b open-label trial provided the first direct head-to-head comparison of tirzepatide and semaglutide for obesity, randomizing 751 adults without diabetes to maximum tolerated doses of tirzepatide (10 or 15mg weekly) or semaglutide (1.7 or 2.4mg weekly) for 72 weeks

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Notably, in the SURMOUNT-1 DXA substudy, visceral fat mass was reduced by 40.1% with tirzepatide compared with 7.3% with placebo [58]