Excessive or prolonged inflammation, however, can impair healing: chronic inflammatory signaling disrupts collagen organization, delays tissue maturation, and can convert an acute injury into a chronic condition
doi:10.1681/ASN.2016060656 [21] Huang YC, Wu MC, Wang YH, Wei JC
Fibroblast cell-culture studies have characterized proliferation, migration, collagen synthesis, and gene-expression endpoints
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