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Almost all efficacy data come from a single research group, and independent replication of the larger-effect-size studies remains limited

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Integrin signaling through elevated integrin 1 and 1 expression mediates cell adhesion to extracellular matrix, cell migration and proliferation, growth factor secretion, and cytoskeleton organization

An independent 2019 systematic review by Gwyer, Wragg, and Wilson in Cell and Tissue Research notably authored outside the original Zagreb research group examined BPC-157 in musculoskeletal soft tissue healing and reported uniformly positive preclinical findings

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