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10.7150/thno.44051 273 ZhuP.HuS.JinQ.LiD.TianF.ToanS.et al (2018)

When deficiency is confirmed, replacement can support blood count recovery and may help prevent worsening nerve problems related to low B12

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Importantly, DSIP exhibits significant inter-individual variability in effects, which may reflect genetic differences in metabolism, receptor expression, or endogenous regulatory systems