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Multiple studies have demonstrated that even large oral doses produce minimal or no increase in plasma glutathione levels in healthy subjects

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Circulating concentrations of choline and betaine and risk of cardiovascular disease A 1995 study had found that elevated blood homocysteine concentrations in patients who experienced a vascular occlusion were associated with higher urinary excretion of betaine, rather than with reduced intake of choline or betaine or diminished activity of BHMT (49)