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Runx2/Osterix pathway: Upregulation of Runx2 (osteogenic differentiation core transcription factor) and Osterix expression induces directed differentiation of bone marrow mesenchymal stem cells into osteoblasts and increases new bone formation

However, in one case, psychotic symptoms and seizures recurred despite continuous cyanocobalamin replacement therapy after the discontinuation of antipsychotic and antiseizure medications [90]

Clinical studies As summarized above, a multitude of preclinical studies have investigated the therapeutic effects of stimulating NAD + metabolism to ameliorate symptoms of aging and various pathologies, yielding promising results

doi:10.1016/j.psychres.2018.02.056 88 Grant, J

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