This favorable safety margin provides reassurance, though extrapolation from animals to humans always involves uncertainty
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Obesity Mechanistic: Hypothalamic satiety circuit research and food intake regulation modelling
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34 Consequently, turnover of 5,10-methyleneTHF via the TYMS enzyme is proposed to be greater in 3R3R individuals, with a decrease in this vitamer and an increase in homocysteine levels previously observed in such individuals