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In the zona glomerulosa of the adrenal cortex, activation of AT 1 R triggers the release of mineralocorticoids [149], which elevate blood pressure primarily via stimulation of sodium reabsorption and expansion of plasma volume, and secondarily via non-genomic mineralocorticoid receptor (MR)-mediated actions [155]

References 1.Zunz E., La Barre J

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Thus, oncogene activation is likely to increase the expression of NRF2, negating the need for mutations in NRF2 or KEAP1