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These apply regardless of medication status, but they carry extra relevance for people navigating the physiological changes that tirzepatide produces

The more recent semaglutide trials (ADJUST T1D) reported up to 30% insulin dose reduction alongside weight loss and improved time in range

Exendin-4 reduced food intake as expected, but the effect was weakened when DBI was blocked

While some studies attribute beneficial effects of weight loss and amelioration of metabolic syndrome to Oscillospira , an increased abundance has also been linked to a high-fat diet in different rodent models as well as diabetes and inflammation in type 2 diabetes rat models [56, 58]

Joana Nicolau has received fees for presentations and consulting on behalf of Sanofi, Novo Nordisk, Lilly, Boehringer-Ingelheim, Fresenius, AstraZeneca, Fresenius, Dexcom, Amgen, and Senseonics