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Oral supplements might serve as maintenance between injection cycles

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However, this process is non-selective and influenced by regional differences in receptor density, blood flow, and hormonal sensitivity

Indeed, Kang reported that human volunteers who ingested supratherapeutic doses of APAP (80 mg/kg) excreted dramatically lower amounts of APAP oxidative (CYP450) metabolites in urine when treated with fomepizole ( Figure 21 )