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3.3 Fat Metabolism While Hexarelin is not a metabolic peptide in the same class as Semaglutide or Tirzepatide, elevated GH/IGF-1 signaling drives: Increased lipolysis (fat breakdown) Enhanced fatty acid oxidation Reduction in visceral adipose tissue Tesamorelin, an FDA-approved GHRH analog, received approval specifically for visceral fat reduction demonstrating that GH-axis stimulation has meaningful metabolic effects

However, research demonstrates BPC-157 suppresses Ki-67 markers and downregulates VEGF in tumor models, suggesting potential anti-cancer rather than pro-cancer effects

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Angiogenesis and Blood Flow BPC-157 upregulates vascular pathways, particularly VEGF-related signaling and nitric oxide pathways (Akt-eNOS axis), promoting angiogenesis and improved perfusion. 2

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