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Lipophilic drugs can cross the RBC lipid membrane by simple diffusion, while hydrophilic compounds can enter due to the aqueous channels or other membrane-facilitated or active transport systems such as Glut1 (Magnani et al., 2012)

What's more, if you're experiencing a particularly stubborn case discoloration, an in-office hyperpigmentation treatment may be required to fully even things out

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