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If you already deal with constipation on your GLP-1 , early dosing can make it worse for a few days
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Dig Liver Dis (2010) 42(5):32030
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246 The recent findings of the SELECT study also indicate the therapeutic potential of GLP-1 receptor analogues to improve cardiovascular outcomes in overweight and obese individuals without T2D, as weekly administered semaglutide was found to be superior to placebo in reducing the incidence of death from cardiovascular disease, nonfatal myocardial infarction and nonfatal stroke
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