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Keywords: GLP-1 receptor agonists, obesity, weight loss, non-diabetic patients, cardiovascular outcomes, cost-effectiveness Introduction Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern [7] [8]

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however, peripheral serotonin can indirectly modulate brain function and influence central neurotransmission through vagal pathways and neuro-endocrine signaling, although this relationship is complex and not fully understood (Sbrini et al., 2022)

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